Proteomics Studies Supporting Innovations in Modern Medicine
Proteomics studies play a vital role in medications discovery because they can help find proteins that are key to the development of a disease. By studying how proteins work and interact with each other, researchers can develop more targeted and effective medications.
Proteomics technologies such as mass spectrometry make it easier to map protein changes that occur in the body, both in healthy and diseased conditions. This opens up great opportunities to create medications with fewer side effects and greater benefits.
Proteomics is also an important foundation in personalized medicine. Through protein analysis, doctors can understand how a person's body responds to certain treatments.
The proteomics approach allows therapies to be designed according to individual needs, making treatment more effective. With these benefits, proteomics not only helps understand diseases, but also brings hope for more precise and appropriate treatments for each person.
What Is Proteomics?
What is Proteomics?
Proteomics is a branch of science that studies the entire collection of proteins produced by a cell, known as the proteome. This study includes various important activities, such as identifying the types of proteins present and measuring their amounts (quantification), determining the location of proteins in cells or tissues, and understanding the structure, function, and interactions between proteins.
In addition, proteomics also studies protein expression profiles, namely when and how proteins are produced, and the changes or modifications that occur in these proteins. By studying these aspects, proteomics provides deeper insight into biological activity in the body, which is very important for understanding cell function and disease mechanisms.
Types of Proteomics and Their Functions
Proteomics can be divided into three main types: expression proteomics, structural proteomics, and functional proteomics, each of which has a different focus and purpose.
1.Expression proteomics
Expression proteomics studies the differences in the amount and type of proteins produced by a sample, for example between healthy cells and diseased cells, or cells exposed to medications. Researchers use techniques like 2D gel electrophoresis, mass spectrometry, and microarrays to find new proteins that may play a role in disease or other important processes, such as cellular signaling.
2.Structural proteomics
Structural proteomics focuses on mapping the three-dimensional shapes of proteins and how they are arranged in cells. Structural proteomics also studies how proteins interact with each other to help find the right targets for medications development. For example, methods like X-ray crystallography and NMR spectroscopy are used to understand complex structures inside cells, such as nuclear pores.
3.Functional proteomics
Functional proteomics studies what proteins do in the body, how they work, and how they interact with each other. If a protein is found to be associated with other proteins in a particular mechanism, it is likely to play a role in that process, such as metabolism or the body’s response to stimuli.
These three types of proteomics help us understand the role of proteins in the body from a variety of perspectives, from their number, shape, to their function.
Proteomics Applications in Pharmaceutical Development
Proteomics plays a vital role in medications discovery. It helps to find medication targets, develop more effective medications, and evaluate the effects of medications on patients.
Older methods such as 2-DE (two-dimensional gel electrophoresis) have limitations, such as the difficulty of separating membrane proteins (which are often medications targets) and detecting proteins in small amounts. To overcome this, modern technologies such as Mass Spectrometry (MS), protein-chips, and activity-based assays are used to analyze proteins more accurately.
Advances in proteomics and computer technology have accelerated the medications discovery process. With this technology, researchers can screen proteins in clinical samples to find disease biomarkers, identify medication targets, and create more effective and safe medications.
This proteomics technology helps to understand how patients respond to therapy, so that medications can be developed more precisely. With proteomics, the medication discovery process becomes faster, more efficient, and more targeted.
Proteomics also plays a vital role in personalized medicine by helping to understand patient protein and metabolite data. This technology enables the identification of unique biomarkers for diagnosis, prognosis, and response to therapy, so that treatment can be tailored to individual needs.
The systems biology approach studies the relationships between events in the body to understand how molecular changes cause disease. In this way, proteomics helps create more specific therapies, avoid side effects, and improve treatment success.
Laboratory testing of pharmaceutical products at IML Research
With so many benefits of proteomics in drug discovery and development, it is crucial to ensure the accuracy of research results. To ensure the quality, effectiveness, and safety of drugs before they are marketed, IML Research provides reliable lab testing services. We help pharmaceutical businesses obtain accurate and reliable data with advanced technology and expert staff. Now is the time to get your drug lab tested at IML Research to ensure the highest standards for every product you develop!
Author: Dherika, Editor: Sabilla
References
Aslam, B., Basit, M., Muhammad, A.N., Mohsin, K., & Muhammad, H.R. (2017). Proteomics: Technologies and their applications. Journal of Chromatographic Science, 55(2), 182–196. Doi: 10.1093/chromsci/bmw167.
Gobena, S., Admassu, b., Mebrie, Z.K., & Abebe, T.G. (2024). Proteomics and Its Current Application in Biomedical Area: Concise Review. The Scientific World Journal, 2024: 1-13. https://doi.org/10.1155/2024/4454744.
